Endocrine Abstracts

Generously supported by IPSEN)-->GH replacement (GHR) in adults has demonstrated to improve body composition, inflammatory cardiovascular biomarkers and quality of life. However, this benefit is uneven, and factors that stratify treatment response are required.According to current guidelines, low IGF-I levels in specific conditions provide strong evidence for GH deficiency (GHD). Nevertheless, normal levels do ...

Transsphenoidal adenomectomy (TSA) is the recommended primary therapy in most patients with acromegaly and results in remission for majority of microadenomas and a proportion of macroadenomas depending on extent of surgically accessible disease. Acromegaly is associated with significant mortality and morbidity, hence a combination of treatment modalities may be needed to achieve disease control.Methods: A retrospective casenotes review was conducted and ...

Response to therapy re-stratification approach has been recently included in the 2015 ATA guidelines as a risk-adapted approach to management of thyroid cancer. Our aim was to investigate the clinical utility of response to therapy variables obtained during early follow-up in combination with BRAF, a prominent oncogene in thyroid cancer with prognostic value. This was a retrospective multicenter study of 871 patients at 11 centers in Spain with papillary thyroid cancer followe...

Introduction: The most frequent causes of ACTH-dependent Cushing’s syndrome are of pituitary origin and, less frequently, due to ectopic secretion of bronchial carcinoid, small cell lung cancer, and neuroendocrine tumors; it is rarely caused by an ACTH-producing pheochromocytoma.Methodology: We present a case of a 44-year-old female with a history of poorly controlled type 2 diabetes, hypertension, and long-standing obesity with no genetic predispos...